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Capture-based SNP Genotyping with Twist Target Enrichment Panels
Arrays have long been the go-to method for the large scale genotyping of single nucleotide polymorphisms (SNPs).
This application note demonstrates how Twist Custom Target Enrichment Panels can be designed for the identification of hundreds of thousands of markers by NGS. Variant calling performance is evaluated using genomic genotyping standards and compared directly with arrays, demonstrating accurate genotyping with minimal bias. SNP and indel genotyping can now be performed on the same platform as whole-exome sequencing, reducing costs, time, and effort.
Covered in this Application Note
How Twist’s Target enrichment panels can be used to accurately identify hundreds of thousands of SNPs
How genotyping by sequencing can be performed accurately w/minimal biases & call rates that match or exceed array based genotyping
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